Clinical significance of tumor-stroma ratio in head and neck cancer : a systematic review and meta-analysis

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annif.suggestionscancerous diseases|head|neck|oral cancer|forecasts|squamous cell carcinoma|tumours|nape of the neck|laryngitis|diagnostics|enen
annif.suggestions.linkshttp://www.yso.fi/onto/yso/p678|http://www.yso.fi/onto/yso/p7887|http://www.yso.fi/onto/yso/p2730|http://www.yso.fi/onto/yso/p16044|http://www.yso.fi/onto/yso/p3297|http://www.yso.fi/onto/yso/p27078|http://www.yso.fi/onto/yso/p2299|http://www.yso.fi/onto/yso/p12866|http://www.yso.fi/onto/yso/p28949|http://www.yso.fi/onto/yso/p416en
dc.contributor.authorAlmangush, Alhadi
dc.contributor.authorAlabi, Rasheed Omobolaji
dc.contributor.authorTroiano, Giuseppe
dc.contributor.authorColetta, Ricardo D.
dc.contributor.authorSalo, Tuula
dc.contributor.authorPirinen, Matti
dc.contributor.authorMäkitie, Antti A.
dc.contributor.authorLeivo, Ilmo
dc.contributor.facultyfi=Tekniikan ja innovaatiojohtamisen yksikkö|en=School of Technology and Innovations|-
dc.contributor.organizationfi=Vaasan yliopisto|en=University of Vaasa|
dc.date.accessioned2022-03-10T11:40:53Z
dc.date.accessioned2025-06-25T13:27:32Z
dc.date.available2022-03-10T11:40:53Z
dc.date.issued2021-04-30
dc.description.abstractBackground The clinical significance of tumor-stroma ratio (TSR) has been examined in many tumors. Here we systematically reviewed all studies that evaluated TSR in head and neck cancer. Methods Four databases (Scopus, Medline, PubMed and Web of Science) were searched using the term tumo(u)r-stroma ratio. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were followed. Results TSR was studied in nine studies of different subsites (including cohorts of nasopharyngeal, oral, laryngeal and pharyngeal carcinomas). In all studies, TSR was evaluated using hematoxylin and eosin staining. Classifying tumors based on TSR seems to allow for identification of high-risk cases. In oral cancer, specifically, our meta-analysis showed that TSR is significantly associated with both cancer-related mortality (HR 2.10, 95%CI 1.56–2.84) and disease-free survival (HR 1.84, 95%CI 1.38–2.46). Conclusions The assessment of TSR has a promising prognostic value and can be implemented with minimum efforts in routine head and neck pathology.-
dc.description.notification© The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.-
dc.description.reviewstatusfi=vertaisarvioitu|en=peerReviewed|-
dc.format.bitstreamtrue
dc.format.contentfi=kokoteksti|en=fulltext|-
dc.format.extent8-
dc.identifier.olddbid15574
dc.identifier.oldhandle10024/13635
dc.identifier.urihttps://osuva.uwasa.fi/handle/11111/2136
dc.identifier.urnURN:NBN:fi-fe2022031022924-
dc.language.isoeng-
dc.publisherBioMed Central-
dc.relation.doi10.1186/s12885-021-08222-8-
dc.relation.funderTurku University Hospital Fund-
dc.relation.funderHelsinki University Hospital Research Fund-
dc.relation.funderFinnish Cancer Society-
dc.relation.funderFinska Läkaresällskapet-
dc.relation.funderthe Maritza and Reino Salonen Foundation-
dc.relation.ispartofjournalBMC Cancer-
dc.relation.issn1471-2407-
dc.relation.issue1-
dc.relation.urlhttps://doi.org/10.1186/s12885-021-08222-8-
dc.relation.volume21-
dc.rightsCC BY 4.0-
dc.source.identifierWOS:000654943400001-
dc.source.identifierhttps://osuva.uwasa.fi/handle/10024/13635
dc.subjectClinical relevance-
dc.subjectHead and neck cancer-
dc.subjectMarker-
dc.subjectSystematic review and meta-analysis-
dc.subjectTumor-stroma-
dc.subjectTumor-stroma ratio-
dc.subject.disciplinefi=Tietoliikennetekniikka|en=Telecommunications Engineering|-
dc.titleClinical significance of tumor-stroma ratio in head and neck cancer : a systematic review and meta-analysis-
dc.type.okmfi=A2 Katsausartikkeli tieteellisessä aikakauslehdessä|en=A2 Peer-reviewed review article|sv=A2 Översiktsartikel i en vetenskaplig tidskrift|-
dc.type.publicationarticle-
dc.type.versionpublishedVersion-

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